THE ANTITUMORAL COMPOUND KAHALALIDE-F ACTS ON CELL LYSOSOMES

Authors
GARCIAROCHA M BONAY P AVILA J
Citation
M. Garciarocha et al., THE ANTITUMORAL COMPOUND KAHALALIDE-F ACTS ON CELL LYSOSOMES, Cancer letters, 99(1), 1996, pp. 43-50
Citations number
15
Categorie Soggetti
Oncology
Journal title
Cancer letters → ACNP
ISSN journal
03043835
Volume
99
Issue
1
Year of publication
1996
Pages
43 - 50
Database
ISI
SICI code
0304-3835(1996)99:1<43:TACKAO>2.0.ZU;2-W
Abstract
The target for the antitumoral peptidic drug, Kahalalide F, has been s tudied in cultured cells. In the presence of the compound, the cells b ecame impressively swollen, showing the formation of large vacuoles. T he formation of these vacuoles appears to be the consequence of change s in lysosomal membranes. Thus, lysosomes are a target for Kahalalide F action.