TRANS,TRANS-2,4-DECADIENAL - CYTOTOXICITY AND EFFECT ON GLUTATHIONE LEVEL IN HUMAN ERYTHROLEUKEMIA (HEL) CELLS

Authors
NAPPEZ C BATTU S BENEYTOUT JL
Citation
C. Nappez et al., TRANS,TRANS-2,4-DECADIENAL - CYTOTOXICITY AND EFFECT ON GLUTATHIONE LEVEL IN HUMAN ERYTHROLEUKEMIA (HEL) CELLS, Cancer letters, 99(1), 1996, pp. 115-119
Citations number
24
Categorie Soggetti
Oncology
Journal title
Cancer letters → ACNP
ISSN journal
03043835
Volume
99
Issue
1
Year of publication
1996
Pages
115 - 119
Database
ISI
SICI code
0304-3835(1996)99:1<115:T-CAEO>2.0.ZU;2-H
Abstract
The effects of trans,trans-2,4-decadienal (DDE), an isomer of a lipid peroxidation product were investigated on the human erythroleukemia ce ll line (HEL TIB 180). DDE strongly inhibits cell growth and affects c ell viability without any differentiating effects. DDE treatment of HE L cells leads to a marked variation of the cellular glutathione level (GSH) and is involved in the beginning of DNA fragmentation.