NONINVASIVE DETECTION OF IBUPROFEN IN-VIVO C-13-NMR SIGNALS IN RATS

Authors
CHEN CN WANG PC SONG HF LIU YC CHEN CS
Citation
Cn. Chen et al., NONINVASIVE DETECTION OF IBUPROFEN IN-VIVO C-13-NMR SIGNALS IN RATS, Chemical and Pharmaceutical Bulletin, 44(1), 1996, pp. 204-207
Citations number
27
Categorie Soggetti
Pharmacology & Pharmacy",Chemistry
Journal title
Chemical and Pharmaceutical Bulletin → ACNP
ISSN journal
00092363
Volume
44
Issue
1
Year of publication
1996
Pages
204 - 207
Database
ISI
SICI code
0009-2363(1996)44:1<204:NDOIIC>2.0.ZU;2-W
Abstract
A non-invasive in vivo C-13-NMR experiment is performed to follow the metabolic pathway of ibuprofen in rats. Detection of possible intermed iates and the stereoselectivity of ibuprofen chiral inversion process are discussed.