AN UNUSUAL FLUORIDE-MEDIATED OXIDATION OF GITOXIN

Authors
NAGATSU A NAKAMURA Y TAKEMOTO K NAGAI S UEDA T HATANO K SAKAKIBARA J HASHIMOTO T ASAKAWA Y
Citation
A. Nagatsu et al., AN UNUSUAL FLUORIDE-MEDIATED OXIDATION OF GITOXIN, Chemical and Pharmaceutical Bulletin, 44(1), 1996, pp. 258-260
Citations number
4
Categorie Soggetti
Pharmacology & Pharmacy",Chemistry
Journal title
Chemical and Pharmaceutical Bulletin → ACNP
ISSN journal
00092363
Volume
44
Issue
1
Year of publication
1996
Pages
258 - 260
Database
ISI
SICI code
0009-2363(1996)44:1<258:AUFOOG>2.0.ZU;2-M
Abstract
An unusual oxidative transformation of alpha,beta-unsaturated gamma-la ctone of the cardenolide gitoxin (1a) by tetra-n-butylammonium fluorid e (TBAF) is reported. The structure of the product (2a) was finally co nfirmed by an X-ray crystal structure analysis of its genin (2b). The oxidation proceeded also in the presence of CsF, and KF + 18-crown-6.