STEREOSELECTIVE FUNCTIONALIZATION AT C-9 OF RETINAE - SYNTHESIS OF 9-TRANS-19-NOR-9-HALORETINAL ANALOGS

Authors
SHINADA T YOSHIHARA K
Citation
T. Shinada et K. Yoshihara, STEREOSELECTIVE FUNCTIONALIZATION AT C-9 OF RETINAE - SYNTHESIS OF 9-TRANS-19-NOR-9-HALORETINAL ANALOGS, Chemical and Pharmaceutical Bulletin, 44(1), 1996, pp. 264-266
Citations number
12
Categorie Soggetti
Pharmacology & Pharmacy",Chemistry
Journal title
Chemical and Pharmaceutical Bulletin → ACNP
ISSN journal
00092363
Volume
44
Issue
1
Year of publication
1996
Pages
264 - 266
Database
ISI
SICI code
0009-2363(1996)44:1<264:SFACOR>2.0.ZU;2-L
Abstract
Stereoselective functionalization at C-9 of retinal based on the use o f the C-4+X-unit is described. A sequential linkage of C-4+X-units (X= Cl, Br, and I) with ylide 8 (C-10) and phosphonate 12 (C-5) selectivel y gave 9-trans-19-nor-9-Cl, Br, and I-retinal derivatives.