AUTOPSIES OF SUDDEN-INFANT-DEATH-SYNDROME - CLASSIFICATION AND EPIDEMIOLOGY

An enquiry into sudden infant death syndrome (SIDS) in 1987 furnished us with detailed epidemiological data for 281 cases that underwent a t horough post-mortem examination. This analysis uses these data to eval uate the role the autopsy plays in explaining sudden death. The cases were classified into three diagnostic groups: explained causes of deat h (group 1), unexplained deaths with anomalies (group 2), and no anoma ly (group 3). These 281 cases show the three essential features that c haracterize SIDS: over-representation of males, increased deaths durin g the second and third months of life, and increased deaths during win ter. The autopsy examination revealed that many of these deaths had a medical explanation. Almost half were assigned to group 1. At the time of autopsy, no precise pathology could be diagnosed for 147 deaths; o f these, 140 showed histological anomalies. There were only seven sudd en deaths for which no abnormal sign was evident at the autopsy. These results are compared with those of similar studies and discussed in c onnection with three factors: the initial selection of cases, the natu re and degree of the investigations, and the possible interpretations of the symptoms uncovered.