The records of 98 patients with 160 hypoplastic thumbs seen between 19
23 and 1993 were reviewed to determine the salient characteristics of
this population. Physical findings, photographs, and x-ray films were
studied. Sixty-three percent of patients were male, and 63% had bilate
ral thumb hypoplasia, 59% had radial dysplasia, and 86% had other anom
alies. An associated syndrome, most commonly the vertebral, anal, trac
heosophageal, renal, and radial limb anomalies association or Holt-Gra
m syndrome, was present in 44%. Patients with spine, genitourinary, or
gastrointestinal anomalies were mast likely to have the vertebral, an
al, tracheosophageal, renal, and radial limb anomalies association, th
ose with cardiac anomalies were most likely to have Holt-Gram syndrome
, and those with lower extremity anomalies were most likely to have a
different syndrome. One hundred thirty-nine thumbs were classifiable,
using a modification of Blauth's classification; 19% were types 1 and
2, 23% were type 3, and 58% were types 4 and 5. One hundred seven oper
ations were performed on 63 upper limbs, including 24 thumb reconstruc
tions and 35 pollicitations. These patients must be carefully examined
for bilaterality, other anomalies, and syndromes. Classification usin
g a modification of Blauth's criteria is useful and helps the surgeon
determine a treatment plan.