THE GENE FOR CALCIUM-MODULATING CYCLOPHILIN LIGAND (CAMLG) IS LOCATEDON HUMAN-CHROMOSOME 5Q23 AND A SYNTENIC REGION OF MOUSE CHROMOSOME-13

The CAMLG gene encodes a novel cyclophilin B-binding protein called ca lcium-modulating cyclo-philin ligand, which appears to be involved in the regulation of calcium signaling in T lymphocytes and other cells. The murine homolog, Caml, was localized by interspecific backcross ana lysis to the middle of chromosome 13. Ey fluorescence in situ hybridiz ation, this gene was localized to human chromosome 5 in a region (q23) known to be syntenic to mouse chromosome 13. These results provide fu rther evidence supporting the extensive homology between human chromos ome 5q and mouse chromosome 13. In addition, the results will provide a basis for further evaluation of cytogenetic anomalies that may contr ibute to inherited defects in calcium signaling or immune system funct ion. (C) 1996 Academic Press, Inc.