GENETIC-MAPPING OF 2 LOCI, DXS454 AND DXS458, WITH RESPECT TO THE X-LINKED AGAMMAGLOBULINEMIA GENE LOCUS

Authors
PARKAR M LOVERING R LEVINSKY RJ KINNON C
Citation
M. Parkar et al., GENETIC-MAPPING OF 2 LOCI, DXS454 AND DXS458, WITH RESPECT TO THE X-LINKED AGAMMAGLOBULINEMIA GENE LOCUS, Human genetics, 93(1), 1994, pp. 89-90
Citations number
7
Categorie Soggetti
Genetics & Heredity
Journal title
Human genetics → ACNP
ISSN journal
03406717
Volume
93
Issue
1
Year of publication
1994
Pages
89 - 90
Database
ISI
SICI code
0340-6717(1994)93:1<89:GO2LDA>2.0.ZU;2-2
Abstract
The dinucleotide repeat sequences at the DXS454 and DXS458 loci have b een mapped genetically to Xq22, to the interval between DXS3 and DXS17 . We have now mapped them with respect to XLA and five other loci, to within the DXS3 to XLA interval. The more precise localisation of thes e polymorphic loci will be useful for the fine-mapping of disease loci on the long arm of the X chromosome and enable these probes to be use d for prenatal diagnosis and carrier status determination in families with XLA.