DETECTION BY THE POLYMERASE CHAIN-REACTION OF 2 POLYMORPHISMS IN EXON-14 OF THE HUMAN INTER-ALPHA-TRYPSIN INHIBITOR HEAVY-CHAIN H1 GENE

Authors
THIBERVILLE L BOURGUIGNON J BELDJORD C DIARRAMEHRPOUR M NOUVET G MARTIN JP
Citation
L. Thiberville et al., DETECTION BY THE POLYMERASE CHAIN-REACTION OF 2 POLYMORPHISMS IN EXON-14 OF THE HUMAN INTER-ALPHA-TRYPSIN INHIBITOR HEAVY-CHAIN H1 GENE, Human genetics, 93(1), 1994, pp. 91-92
Citations number
6
Categorie Soggetti
Genetics & Heredity
Journal title
Human genetics → ACNP
ISSN journal
03406717
Volume
93
Issue
1
Year of publication
1994
Pages
91 - 92
Database
ISI
SICI code
0340-6717(1994)93:1<91:DBTPCO>2.0.ZU;2-6
Abstract
Two polymorphisms were detected within exon 14 of the inter-alpha-tryp sin inhibitor heavy chain H1 (ITIH1) gene. The polymorphisms are detec ted by digesting the same 202-bp polymerase reaction product with the PstI and Hph1 restriction endonucleases. These gene polymorphisms lead to the change of two amino acids in the mature protein. The polymorph isms can be used for the analysis of 3p21 deletion in human carcinomas as well as to develop a better understanding of the protein polymorph ism already described.