IMPROVEMENT IN RHEUMATOID-ARTHRITIS FOLLOWING APPLICATION OF AN EXTRACORPOREAL GRANULOTRAP COLUMN, G-1

Patients with rheumatoid arthritis (RA) showed significantly (P<0.01) increased numbers of granulocytes in their peripheral blood compared w ith normal donors and patients with osteoarthritis, and this finding c orrelated with interleukin-6 and C-reactive protein levels and active joint score. Then, 17 patients with RA were treated eight times in 4 w eeks with a newly developed extracorporeal granulotrap column containi ng cellulose acetate beads (G-1 column). This column reduced granulocy tes in the outflow blood by 50.2% compared with inflow counts. To eval uate the efficacy of G-1 therapy, 17 patients were followed for 12 wee ks from the beginning of this therapy. The modified Lansbury index (LI ) for monitoring RA activity significantly improved from a pretretamen t mean score of 60.8% to a posttreatment score of 51.3%. The lowered s cores were maintained up to 12 weeks after the initiation of therapy. Of the four LI items, tender and swollen joint scores showed the most significant improvement, with the tender joint score showing a particu larly significant decrease throughout the study period. No serious sid e-effects were observed. These findings suggested that G-1 therapy was effective for RA.