2ND-GENERATION ANTIMALARIAL ENDOPEROXIDES

Artemisinin, derived from a Chinese herbal remedy, is a potent peroxid e-containing antimalarial. New types of peroxides, derived from this s tructure, as well as other naturally occurring antimalarial peroxides, have been synthesized and found to have potent antimalarial activitie s. Studies on the activities, modes of action, and toxicities of these compounds are discussed here by Steven Meshnick and colleagues.