MICROBIAL REDUCTION OF METHYL-SUBSTITUTED BICYCLO[3.2.0]HEPT-3-EN-6-ONES - A SCREENING TO HOMOCHIRAL ENDO-ALCOHOLS AND EXO-ALCOHOLS

Authors
FANTIN G FOGAGNOLO M MEDICI A PEDRINI P MAROTTA E MONTI M RIGHI P
Citation
G. Fantin et al., MICROBIAL REDUCTION OF METHYL-SUBSTITUTED BICYCLO[3.2.0]HEPT-3-EN-6-ONES - A SCREENING TO HOMOCHIRAL ENDO-ALCOHOLS AND EXO-ALCOHOLS, Tetrahedron : asymmetry, 7(1), 1996, pp. 277-282
Citations number
14
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Inorganic & Nuclear","Chemistry Physical
Journal title
Tetrahedron : asymmetry → ACNP
ISSN journal
09574166
Volume
7
Issue
1
Year of publication
1996
Pages
277 - 282
Database
ISI
SICI code
0957-4166(1996)7:1<277:MROMB>2.0.ZU;2-6
Abstract
Various yeast and mould strains were tested in the microbial reduction of methyl-substituted bicyclo[3.2.0]hept-3-en-6-ones 1a-c. The endo-a lcohols 2a-c were obtained with good yields and enantiomeric excess, L ower yields are described for the eno-alcohols 3a-e which are normally enantiomerically pure. Comparisons with microbial reduction of bicycl o[3.2.0]hept-2-en-6-one 1d and bicyclo[3.3.0]oct-7-en-2-one 1e are als o reported.