SYNTHESIS AND IN-VITRO PHARMACOLOGY OF A SERIES OF NEW 1,4-DIHYDROPYRIDINES .2. DIETHYL ,6-DIMETHYL-1,4-DIHYDROPYRIDINE-3,5-DICARBOXYLATES AND THEIR CORRESPONDING ISOTHIOUREAS AS TOOLS FOR DETERMINING STRUCTURE-ACTIVITY-RELATIONSHIPS

The synthesis, in vitro calcium channel blocking activities and the af finities for the Ca2+-entry receptor protein, of a new series of dieth yl oxy)phenyl]-1,4-dihydropyridine-3,5-dicarboxylates are discussed. I ncreasing the omega-substituted alkoxy chain length from pentoxy to de coxy is found not to affect the calcium channel blocking activity or a ffinity in both diethyl 2,6-dimethyl-1,4dihydropyridine-3,5-dicarboxyl ates and diethyl 2,6-dimethyl-4-[2-(omega-thiourea omega-thiouronium x y)phenyl]-1,4-dihydropyridine-3,5-dicarboxylates.