SYNTHESIS AND PHARMACOLOGICAL STUDY OF NEW CALCIUM-ANTAGONISTS, ANALOGS OF CINNARIZINE AND FLUNARIZINE

Several phosphonic diethyl esters were synthesized and their calcium a ntagonistic activity evaluated in vitro. The diethyl phosphonate group was condensed on substituted [diphenylmethyl], [(2-benzofuranyl)pheny lmethyl], [(4-(diphenylmethyl-1 piperazinyl) methyl], [4-(4-diphenylme thyl-1-piperazinyl methyl) phenylmethyl], and [4-(3-phenyl-2-propenyl) -1-piperazinyl methyl] groups. Despite the presence of the diethyl pho sphonate moiety and the benzhydrylpiperazinyl group, both present in p otent calcium antagonist structures, only 1 of the 19 synthesized comp ounds exhibited a calcium antagonistic profile.