SYNTHESIS AND PRELIMINARY PHARMACOLOGICAL STUDY OF NEW AMIDINOBENZISOTHIAZOLES

Authors
VICINI P AMORETTI L BALLABENI V BAROCELLI E CHIAVARINI M
Citation
P. Vicini et al., SYNTHESIS AND PRELIMINARY PHARMACOLOGICAL STUDY OF NEW AMIDINOBENZISOTHIAZOLES, European journal of medicinal chemistry, 28(12), 1993, pp. 955-961
Citations number
13
Categorie Soggetti
Chemistry Medicinal
Journal title
European journal of medicinal chemistry → ACNP
ISSN journal
02235234
Volume
28
Issue
12
Year of publication
1993
Pages
955 - 961
Database
ISI
SICI code
0223-5234(1993)28:12<955:SAPPSO>2.0.ZU;2-1
Abstract
Some new N-(1,2-benzisothiazol-3-yl)amidines were synthesized and test ed for antiinflammatory, antipyretic, analgesic and spasmolytic activi ties in comparison with indomethacin and papaverine respectively. The synthesis of the new compounds has been described. All the amidinobenz isothiazoles showed remarkable analgesic action and an interesting ant iphlogistic action, while only one drug displayed a certain antipyreti c activity. As regards spasmolytic activity, 3 compounds out of 6 demo nstrated a papaverine-like effect.