PREPARATIONS OF ANTIFUNGAL SCH-42427 SM-9164 - PREPARATIVE CHROMATOGRAPHIC RESOLUTION, AND TOTAL ASYMMETRIC-SYNTHESIS VIA ENZYMATIC PREPARATION OF CHIRAL ALPHA-HYDROXY ARYLKETONES/

Authors
GALA D DIBENEDETTO DJ CLARK JE MURPHY BL SCHUMACHER DP STEINMAN M
Citation
D. Gala et al., PREPARATIONS OF ANTIFUNGAL SCH-42427 SM-9164 - PREPARATIVE CHROMATOGRAPHIC RESOLUTION, AND TOTAL ASYMMETRIC-SYNTHESIS VIA ENZYMATIC PREPARATION OF CHIRAL ALPHA-HYDROXY ARYLKETONES/, Tetrahedron letters, 37(5), 1996, pp. 611-614
Citations number
21
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
37
Issue
5
Year of publication
1996
Pages
611 - 614
Database
ISI
SICI code
0040-4039(1996)37:5<611:POASS->2.0.ZU;2-P
Abstract
Efficient approaches towards the preparation of chiral azole antifunga ls Sch 42427/ SM 9164 (1) via large scale chromatographic separation o f its enantiomers, or via enzymatic syntheses of key chiral intermedia tes alpha-hydroxy arylketones 5 in excellent enantiomeric excesses (ee s) are described.