CONFORMATIONALLY CONSTRAINED SEROTONIN ANALOGS - STEREOSELECTIVE SYNTHESIS OF TRANS-3-(2-AMINOCYCLOALKYL)INDOLES BY AZIRIDINE RING-OPENING

Authors
EZQUERRA J PEDREGAL C LAMAS C PASTOR A ALVAREZ P VAQUERO JJ
Citation
J. Ezquerra et al., CONFORMATIONALLY CONSTRAINED SEROTONIN ANALOGS - STEREOSELECTIVE SYNTHESIS OF TRANS-3-(2-AMINOCYCLOALKYL)INDOLES BY AZIRIDINE RING-OPENING, Tetrahedron letters, 37(5), 1996, pp. 683-686
Citations number
24
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
37
Issue
5
Year of publication
1996
Pages
683 - 686
Database
ISI
SICI code
0040-4039(1996)37:5<683:CCSA-S>2.0.ZU;2-T
Abstract
Trans-3-(2-aminocyclopentyl)indoles 9a,c and trans-3-(2-aminocyclohexy l)indoles 9b,d have been stereoselectively prepared by nucleophilic ri ng opening reaction of N-Boc cycloalkylaziridines 6a,b and the ''lower order'' magnesium cuprate II, generated from the corresponding indoli lmagnesium bromides derived from 7a,b.