OXIDATIONS WITH POTASSIUM-PERMANGANATE METAL SULFATES AND NITRATES - BETA-SELECTIVE EPOXIDATION OF DELTA(5)-UNSATURATED STEROIDS

Authors
SALVADOR JAR MELO MLSE NEVES ASC
Citation
Jar. Salvador et al., OXIDATIONS WITH POTASSIUM-PERMANGANATE METAL SULFATES AND NITRATES - BETA-SELECTIVE EPOXIDATION OF DELTA(5)-UNSATURATED STEROIDS, Tetrahedron letters, 37(5), 1996, pp. 687-690
Citations number
14
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
37
Issue
5
Year of publication
1996
Pages
687 - 690
Database
ISI
SICI code
0040-4039(1996)37:5<687:OWPMSA>2.0.ZU;2-J
Abstract
The beta-epoxidation of 3 beta-acetoxy-Delta(5)-unsaturated steroids h as been achieved with numerous potassium permanganate-metal sulphates and nitrates with a high degree of stereoselectivity. 5 beta,6 beta- E poxides are formed in a one step reaction in good yields and using ver y low cost reagents. The best results were achieved with KMnO4/Fe-2(SO 4)(3)n.H2O.