ASYMMETRIC-SYNTHESIS OF (-EPTAZOCINE AND (-)-EPTAZOCINE VIA AN ENZYMATIC-REACTION())

Authors
SHIOTANI S OKADA H YAMAMOTO T NAKAMATA K ADACHI J NAKAMOTO H
Citation
S. Shiotani et al., ASYMMETRIC-SYNTHESIS OF (-EPTAZOCINE AND (-)-EPTAZOCINE VIA AN ENZYMATIC-REACTION()), Heterocycles, 43(1), 1996, pp. 113-126
Citations number
23
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Heterocycles → ACNP
ISSN journal
03855414
Volume
43
Issue
1
Year of publication
1996
Pages
113 - 126
Database
ISI
SICI code
0385-5414(1996)43:1<113:AO(A(V>2.0.ZU;2-M
Abstract
Starting from (R)-3-hydroxy-2-(p-methoxybenzyl)propyl acetate (R-(+)-4 ) prepared by enzymatic monoacetylation of 2-(p-methoxybenzyl)propane- 1,3-diol (3) with lipase PS in the presence of vinyl acetate as an ace tyl donor, lactones ((+)- and (-)-6) were obtained. Using the lactones , (+)- and (-)-eptazocine were synthesized.