COMBINED THERAPEUTIC EFFICACY OF FEW THIOLS WITH CALCIUM DISODIUM VERSENATE DURING ACUTE LEAD-INTOXICATION IN MICE

The efficacy of a few thiol compounds and calcium disodium versenate ( CaNa(2)EDTA), either individually or in combination to acute lead expo sed mice, was investigated. The ability of these chelating agents to r educe liver, kidney, blood and brain lead burden was also determined. Of the thiol compounds examined, the ones which were effective in mobi lizing lead included meso 2,3-dimercaptosuccinic acid (DMSA), sodium 2 ,3-dimercaptopropane-1-sulfonate (DMPS), and S-adenosyl L-methionine ( SAM) beside CaNa(2)EDTA. Further, the combined administration of DMSA or SAM with CaNa(2)EDTA was more effective in reducing the toxic bioch emical effects of lead and tissue lead burden.