ALUMINUM AND PHOSPHORUS URINARY-EXCRETION AFTER MODIFYING GASTRIC-ACID SECRETION IN NORMAL SUBJECTS

Eight healthy volunteers (4 males, 4 females) were prescribed a diet w ith a calorie intake adequate to age and body weight for 3 weeks. In t he second week they were given aluminum hydroxide (Al-hy) 4 g per day in 2 divided doses. In the third week they took Al-hy + omeprazole (20 mg once a day). At the end of the weeks 1, 2, and 3, urine (over a 24 -hour period) and blood samples were collected. The oral load of Al-hy produces increased levels of serum (Al-s) and urine (Al-u) aluminum, while the concomitant use of omeprazole reduces Al-u without modifying Al-s. Omeprazole use has no effect on serum phosphorus levels and doe s not hinder reduction of urine phosphorus excretion caused by Al-hy.