T. Belaiche et al., APPLICATION OF A 2 LEVELS FACTORIAL DESIGN TO THE STUDY OF THE ANTIMICROBIAL ACTIVITY OF 3 TERPENES, Sciences des aliments, 15(6), 1995, pp. 571-578
The antimicrobial activity of three components of eucalyptus essential
oils, i.e. cineol, linalool and eugenol, was determined on Staphyloco
ccus aureus. The use of a 2(3) experimental design method made it poss
ible to reduce the number of trials and to quantify factor-interaction
effects between the compounds studied. 1,8-cineole showed no signific
ant antimicrobial activity, while eugenol was highly active, closely f
ollowed by linalool. The linalool by eugenol interaction showed an ant
agonistic effect between the two substances.