COBALT(II), NICKEL(II), AND COPPER(II) COMPLEXES OF SULFANILAMIDE DERIVATIVES - SYNTHESIS, SPECTROSCOPIC STUDIES, AND ANTIBACTERIAL ACTIVITY, CRYSTAL-STRUCTURE OF [CO(SULFACETAMIDE)(2)(NCS)(2)]

The synthesis and characterization of new coordination compounds of Co (II), Ni(II), and Cu(II) with sulfacetamide (N-[4-(amino-fenil)sulfoni l]acetamide) is reported. The complex [Co(sulfacetamide)(2)(NCS)(2)] c rystallizes in the triclinic space group P-1. The cell dimensions are a = 7.80(2) Angstrom, b = 8.327(9) Angstrom, c = 9.568(3) Angstrom, al pha = 90.5(1)degrees, beta = 90.5(1)degrees, gamma = 97.8(2)degrees, V = 616(1) Angstrom(3), Z = 2, and D-x = 1.689 g/cm(3). The final conve ntional R-factor = 0.039 (R(w) = 0.039) for 3535 ''observed'' reflecti ons and 173 variables. The Co(II) is surrounded in a regular octahedra l arrangement by two N-thyocianato from the NCS, two N-amino and two O -acetamido atoms from the sulfacetamide. Each sulfacetamide, acting as a bidentate ligand, chelates two Co(II) ions as a bridge through the N-amino and the O-acetamido atoms. IR, Reflectance Diffuse, EPR, and m agnetic properties of the obtained complexes are discussed. The comple xes were screened for their activity against E. Coli and S. aureus, sh owing an appreciable antimicrobial activity compared with the ligands.