Background: Tn some diabetic patients, the skin of the hands has a wax
y appearance. Objective: To study subclinical skin stiffening in diabe
tic patients using a noninvasive, in vivo suction device measuring ski
n extensibility and elasticity. Skin thickness was also measured by hi
gh-resolution ultrasonography. Methods: Evaluations were made on the d
orsum of the hands and on the volar aspect of the forearms. Results: I
n type 1 diabetic patients, the extensibility of skin was decreased wh
ile values of thickness and elasticity were increased. These alteratio
ns were most prominent on the hands. Similar modifications, although l
ess pronounced, were also found in type 2 diabetic subjects. Conclusio
n: The reported biomechanical changes indicate the presence of subclin
ical skin stiffening in many patients with diabetes mellitus. Such non
invasive biometrological evaluations could be used for monitoring, rat
ing and correlating some diabetes-associated disorders.