CD4 DEFICIENCY IN MYELODYSPLASTIC SYNDROME WITH MONOSOMY-7

We describe a patient with myelodysplastic syndrome with monosomy 7 pr esenting with a T-cell defect. He suffered from infections from the ag e of 10 years, when a CD4 deficiency and impaired lymphoproliferative responses in vitro were found. The only symptom of a myelodysplastic s yndrome at that time was thrombocytopenia with giant platelets. Monoso my 7 was found in the bone marrow cells. At the age of 11 years he dev eloped other characteristics of monosomy 7 including splenomegaly and anaemia. Some months later leukaemia was diagnosed. Conclusion In non- HIV CD4 deficiency myelodysplastic syndrome has to be considered.