G. Csiko et al., DATA ON THE APPLICABILITY OF ALBENDAZOLE IN DOMESTIC-FOWL .2. TARGET ANIMAL-TOLERANCE STUDIES, Magyar allatorvosok lapja, 50(12), 1995, pp. 864-866
Albendazole (ABZ), similarly to the other benzimidazoles, is less toxi
c in mammalians. Sensitivity of chickens against the effective agent w
as studied during a target animal-toxicological study. Four groups of
10 seven weeks old broiler cocks each were treated via an oral probe o
nce with a 20% suspension of ABZ. The doses used in the groups were 10
, 30 and 50 mg/kg of body-mass, the fourth group served as an untreate
d control. Blood samples were collected before treatment and 6, 24, 48
and 72 hours after treatment to determine the clinicopathological par
ameters (haemoglobin content, packed cell volume, prothrombin clotting
time, aspartate-aminotransferase, lactic acid-dehydrogenase and alkal
ic phosphatase activities, calcium, inorganic phosphate, sodium, potas
sium, chloride, creatinine, glucose, total protein, albumin and globul
in concentrations, Figs 1 to 5). Clinical symptoms did not develop due
to the treatment. Significant changes caused by the treatment were ne
ither found in any of the clinicochemical parameters. Even the five ti
mes higher than the proposed therapeutical dose (10 mg/kg of body-mass
) proved to be innocuous in chickens.