REACTION-DIFFUSION DESCRIPTION OF BIOLOGICAL TRANSPORT PROCESSES IN GENERAL DIMENSION

Authors
Citation
W. Nadler et Dl. Stein, REACTION-DIFFUSION DESCRIPTION OF BIOLOGICAL TRANSPORT PROCESSES IN GENERAL DIMENSION, The Journal of chemical physics, 104(5), 1996, pp. 1918-1936
Citations number
86
Categorie Soggetti
Physics, Atomic, Molecular & Chemical
ISSN journal
00219606
Volume
104
Issue
5
Year of publication
1996
Pages
1918 - 1936
Database
ISI
SICI code
0021-9606(1996)104:5<1918:RDOBTP>2.0.ZU;2-F
Abstract
We introduce a reaction-diffusion system capable of modeling ligand mi gration inside of proteins as well as conformational fluctuations of p roteins, and present a detailed analytical and numerical analysis of t his system in general dimension. The main observable, the probability of finding the system in the starting state, exhibits dimension-depend ent as well as dimension-independent properties, allowing for sharp ex perimental tests of the effective dimension of the process in question . We discuss the application of this theory to ligand migration in myo globin and to the description of gating fluctuations of ion channel pr oteins. (C) 1996 American lnstitute of Physics.