ESTIMATION OF THE RATE AND EXTENT OF CHIRAL INVERSION USING LINEAR-SYSTEMS ANALYSIS

An alternative method based on linear systems analysis is presented fo r the analysis of concentration-time data for the enantiomers of the 2 -arylpropionic acids. This approach uses deconvolution to estimate the rate and extent of chiral inversion with respect to time, assuming li near pharmacokinetics and time invariance, without the need for compli cated modelling procedures. Application to data for the chiral inversi on of ibuprofen in the rat indicates that this approach provides a val id alternative to previous procedures for the analysis of chiral inver sion data. (C) 1995 Wiley-Liss, Inc.