A 19-ALLELE POLYMORPHIC MARKER WITHIN THE CENTROMERE OF HUMAN-CHROMOSOME-5

Authors
PRADES C LAURENT AM YUROV Y PUECHBERTY J ROIZES G
Citation
C. Prades et al., A 19-ALLELE POLYMORPHIC MARKER WITHIN THE CENTROMERE OF HUMAN-CHROMOSOME-5, Cytogenetics and cell genetics, 72(1), 1996, pp. 69-71
Citations number
7
Categorie Soggetti
Cell Biology","Genetics & Heredity
Journal title
Cytogenetics and cell genetics → ACNP
ISSN journal
03010171
Volume
72
Issue
1
Year of publication
1996
Pages
69 - 71
Database
ISI
SICI code
0301-0171(1996)72:1<69:A1PMWT>2.0.ZU;2-V
Abstract
We have detected and characterized a highly polymorphic marker that ma ps to the centromere of human chromosome 5. The localization was estab lished by both linkage analysis within the CEPH reference families and fluorescence in situ hybridization. The marker consists of a sequence of five nucleotides, (CCTTT)(n). Nineteen alleles have been detected in 46 unrelated individuals from 12 CEPH families, with a calculated h eterozygosity of 0.91. This is the first truly centromeric, highly pol ymorphic genetic marker described so far.