MECHANISMS OF CEREBRAL-ISCHEMIA - INTRACELLULAR CASCADES AND THERAPEUTIC INTERVENTIONS

In order to gain insight into the pathophysiology of cerebral ischemia , the focus is on the discrete compartmentalization of neurons and the exquisite homeostasis of the neurochemical, ionic, and molecular envi ronment within these compartments. This review looks at excitotoxic me chanisms of cerebral ischemia spatially by separating presynaptic and postsynaptic events as well as temporally by separating early and late events. Drugs that target these events in the excitotoxic cascade are presented and discussed as potential therapeutic interventions for ce rebral ischemia. Despite a better understanding of the mechanisms of c erebral ischemia through a myriad of animal model studies with various ''neuroprotective'' compounds, the challenge remains to apply this kn owledge to the development of compounds that demonstrate neuroprotecti ve efficacy in terms of quality-of-life outcomes in humans. Copyright (C) 1996 by W.B. Saunders Company.