M. Monane et al., THE IMPACT OF SEDATIVE-HYPNOTIC USE ON SLEEP SYMPTOMS IN ELDERLY NURSING-HOME RESIDENTS, Clinical pharmacology and therapeutics, 59(1), 1996, pp. 83-92
Objective: To determine the frequency of sleep-related complaints amon
g institutionalized elderly subjects and to assess the relationship be
tween perceived sleep quality and the use of sedative-hypnotic agents
and other psychoactive medications. Methods: In 12 nursing homes in Ma
ssachusetts, we conducted observational, cross-sectional, and longitud
inal studies of 145 institutionalized elderly subjects (average age, 8
3.0 years; age range, 65 to 105 years). We recorded the patients' demo
graphic characteristics and all medication use (both scheduled and as
needed) during a 1-month baseline period. A research assistant who was
blinded to diagnoses and medication use performed detailed neuropsych
ologic testing and administered a series of standardized questions con
cerning difficulty sleeping, early morning awakening, and time spent a
wake in bed. Medication use and patient assessments were repeated afte
r a 6-month interval. Results: One or more sleep-related complaints we
re present at baseline in 94 (65%) of the residents studied. Using log
istic regression to adjust for potential confounding, we found no rela
tionship in the baseline month between use of sedative-hypnotic agents
and the presence or absence of sleep complaints. After 6 months of fo
llow-up, 27 (19%) of the residents had decreased their use of sedative
-hypnotic agents and 23 (16%) had increased their use. However, there
was no relationship between decreased use of sedative-hypnotic agents
and worsened sleep (P > 0.20) or between their increased use and impro
ved sleep reports (P > 0.10). Improvement in functional status was sig
nificantly associated with improved sleep at follow-up (P < 0.005). Co
nclusions: Sleep complaints occur in the majority of institutionalized
elderly persons. Neither cross-sectional nor longitudinal analyses sh
owed a relationship between patterns of sedative-hypnotic use and the
presence, absence, or change in sleep complaints.