SYNTHESIS OF 6-MEMBERED COMPOUNDS BY ENVIRONMENTALLY FRIENDLY CYCLIZATION USING INDIRECT ELECTROLYSIS

[Ni(cyclam)](ClO4)(2)-catalyzed indirect electroreduction of olefinic bromides produced six-membered compounds in low to high yields. The sy nthetic intermediate 49 of Ipecac and Corynanthe alkaloids was obtaine d in 88% yield in a highly stereoselective manner. Lactam 66, the synt hetic precursor of tacamonine, was prepared in 49% yield as a mixture of two diastereoisomers. The electrolysis of the bromoacetates gave th e debrominated compounds in good yields.