NONSTEROIDAL ANTIINFLAMMATORY DRUGS LOWER ETHANOL-MEDIATED LIVER INCREASE IN LIPIDS AND THIOBARBITURIC ACID REACTIVE SUBSTANCES

Four nonsteroidal antiinflammatory drugs-namely, acetylsalicylic acid, naproxen, nimesulide, and dipyrone-were assayed to search their capab ility in preventing the hepatic increase of triacylglycerols and thiob arbituric acid reactive substances, as an indication of lipid peroxida tion, resulting from the acute intoxication of rats with ethanol. The four antiinflammatory compounds inhibited the ethanol-mediated increas e in triacylglycerols and thiobarbituric acid reactive substances. Fur thermore, each one of these antiinflammatory drugs produced distinctiv e actions on blood ethanol levels: a temporal diminution with aspirin and naproxen, no changes with nimesulide, and an increase with dipyron e. It is concluded that the nonsteroidal antiinflammatory drugs contri buted to controlling hepatic lipid peroxidation, and hence the oxidati ve stress promoted by ethanol intoxication.