Objective: The authors compared the health-related quality of life of
patients with panic disorder to that of patients with other major chro
nic medical and psychiatric conditions. Method: The physical and menta
l health of a group of 433 patients with current panic disorder and 9,
839 outpatients with psychiatric or medical disorders were assessed wi
th the 20- and 36-item short-form surveys of the Medical Outcomes Stud
y. After controlling for other disease conditions, demographics, and s
tudy site, the authors used multiple regression methods to estimate he
alth-related quality of life levels for panic disorder patients and pa
tients with hypertension, diabetes, heart disease, arthritis, chronic
lung problems, and major depression. Results: Patients with panic diso
rder had levels of mental health and role functioning that were substa
ntially lower than those of patients with depression. However, their p
hysical functioning levels and perceptions of current health more like
those of patients with hypertension and were similar to general popul
ation norms. Conclusions: Panic disorder is a serious societal health
problem with large consequences, and it affects primarily psychologica
l and role domains.