Objective: The aim of this study was to prospectively examine the rela
tionship between immediate and short-term responses to a trauma and th
e subsequent development of posttraumatic stress disorder (PTSD). Meth
od: All patients consecutively admitted to a general hospital were scr
eened for the presence of physical injury due to a traumatic event. Fi
fty-one eligible subjects were assessed 1 week and 6 months after the
trauma. The initial assessment included measures of event severity, pe
ritraumatic dissociation, and symptoms of intrusion, avoidance, depres
sion, and anxiety. The follow-up assessments added the PTSD module of
the Structured Clinical Interview for DSM-III-R-Non-Patient Version an
d the civilian trauma version of the Mississippi Scale for Combat-Rela
ted Posttraumatic Stress Disorder. Results: Thirteen subjects (25.5%)
met PTSD diagnostic criteria at follow-up. Subjects who developed PTSD
had higher levels of peritraumatic dissociation and more severe depre
ssion anxiety, and intrusive symptoms at the 1-week assessment. Peritr
aumatic dissociation predicted a diagnosis of PTSD after 6 months over
and above the contribution of other variables and explained 29.4% of
variance of PTSD symptom intensity. Initial scores on the Impact of Ev
ent Scale predicted PTSD status with 92.3% sensitivity and 34.2% speci
ficity. Symptoms of avoidance that were initially very mild intensifie
d in the subjects who developed PTSD. Conclusions: Peritraumatic disso
ciation is strongly associated with the later development of PTSD. Ear
ly dissociation and PTSD symptoms can help the clinician identify subj
ects at higher risk for developing PTSD.