Background: Frequent, excessive use of over-the-counter or prescriptio
n analgesics may lead to analgesic rebound headache. Little is known a
bout the magnitude of the health problem posed by analgesic rebound he
adache, its epidemiology, the characteristics of analgesic rebound hea
dache sufferers, or about physicians' approaches to treatment. Methods
: Four hundred seventy-three practitioners, who had previously express
ed an interest in the treatment of headache, were mailed a questionnai
re designed to capture information about the frequency and management
of analgesic rebound headache and about the characteristics of analges
ic rebound headache sufferers. Results: Completed questionnaires were
returned by 174 practitioners (37%) from 40 states, the District of Co
lumbia, and Puerto Rico. More than 40% of respondents indicated that a
nalgesic rebound headache was present in at least 20% of their patient
s. On average, the physicians reported that 73% of patients with analg
esic rebound headache were women. Analgesic rebound headache was most
likely to occur in patients aged 31 to 40 years. No one analgesic was
consistently identified as causative, although acetaminophen, butalbit
al + aspirin + caffeine, and aspirin were commonly used by patients. E
ighty percent of respondents indicated that depression was commonly ob
served in analgesic rebound headache sufferers; 77% indicated that phy
sical conditions (especially gastrointestinal symptoms) were commonly
observed. A variety of therapeutic strategies, including pharmacothera
py, were used in the management of analgesic rebound headache. Conclus
ion: Analgesic rebound headache was recognized as a distinct entity an
d a substantive component in more than 40% of the practices of 174 sur
veyed practitioners. General practitioners, who see a wide variety of
patient types with a spectrum of complaints, need to be able to diagno
se analgesic rebound headache by taking a good history.