INHIBITORY MHC CLASS-I RECEPTORS ON NK CELLS AND T-CELLS

Natural Killer (NK) and T cells express receptors for polymorphic majo r histocompatibility complex (MHC) class I molecules, and activation o f these receptors results in inhibition of their effector cell functio n. Genes encoding the murine and human NK-cell receptors have been clo nes, and studies of their structure, function and expression are progr essing rapidly, as reviewed here by Lewis Lanier and Joseph Phillips.