INFLUENCE OF MOCLOBEMIDE ON COGNITIVE FUNCTIONS OF 9 DEPRESSED-PATIENTS - PILOT TRIAL WITH NEUROPHYSIOLOGICAL AND NEUROPSYCHOLOGICAL INDEXES

Authors
GALDERISI S MUCCI A BUCCI P MIGNONE ML MAJ M
Citation
S. Galderisi et al., INFLUENCE OF MOCLOBEMIDE ON COGNITIVE FUNCTIONS OF 9 DEPRESSED-PATIENTS - PILOT TRIAL WITH NEUROPHYSIOLOGICAL AND NEUROPSYCHOLOGICAL INDEXES, Neuropsychobiology, 33(1), 1996, pp. 48-54
Citations number
27
Categorie Soggetti
Psychiatry,Neurosciences,Psychiatry,Neurosciences
Journal title
Neuropsychobiology → ACNP
ISSN journal
0302282X
Volume
33
Issue
1
Year of publication
1996
Pages
48 - 54
Database
ISI
SICI code
0302-282X(1996)33:1<48:IOMOCF>2.0.ZU;2-H
Abstract
Quantitative electroencephalogram (QEEG) changes induced by the acute administration of moclobemide (200 mg) in patients with major depressi on include a transient increase in theta-activity, a slight augmentati on of alpha-activity and a sustained increase in beta-activity. This Q EEG profile distinguishes moclobemide from sedative antidepressants. A 42-day treatment with 400 mg/day of the drug produces a significant d ecrease in the late positive-complex peak latency of the event-related potentials, suggesting a positive effect on attention and cognitive f unctions.