A classification of the lower Mississippi River into geomorphically di
stinct reaches provides an effective framework within which the influe
nce of numerous morphologic variables can be analyzed. A singular real
ization of the river, however, requires that a statistical inference b
e applied to the results which provides a level of assurance to the co
nclusions. A nonparametric method, Multi-Response Permutation Procedur
es (MRPP), is employed to evaluate the significance of channel morphol
ogy variables within an a priori reach classification based upon sinuo
sity and valley slope. An alternative classification is proffered, gen
erated by MRPP, which defines homogeneous subpopulations of the river
as reaches for the collective response of the channel morphology varia
bles. The numeric analyses generate a refinement, by further subdivisi
on, of the original proposed reach structure. Within each reach the mu
ltivariate response of the system can be studied through space and tim
e. Within the time period considered here, 1880 to 1915, the river cha
nnel became progressively wider and shallower. These trends are spatia
lly manifest in fewer longer reaches in 1880 and more shorter reaches
in 1915. This increased variability is concentrated in the areas affec
ted by the Lake County and Monroe uplifts.