Rationale and Objectives. We devised a prediction rule for estimating
pleural effusion volume on the basis of posteroanterior and lateral ch
est radiographs.Methods. A prediction rule was devised for estimating
pleural effusion volume on the basis of the presence or absence of a m
eniscus on chest radiographs. The rule was tested and validated using
separate data sets obtained from a retrospective review of patients ha
ving both a chest radiograph and computed tomography (CT) scan (the go
ld standard) within 24 hr of each other. The accuracy of the predictio
n rule and the degree of interobserver agreement between tile two inde
pendent readers were determined. Results. For the test and validation
sets, the weighted accuracies of the prediction rule were 86% and 85%,
respectively. The respective weighted interobserver agreements were 9
7% and 88%. Pleural effusions became visible as a meniscus on the late
ral chest radiograph at a volume of approximately 50 ml; at a volume o
f 200 ml, the meniscus could be identified on the posteroanterior radi
ograph. At a volume of about 500 ml, the meniscus obscured the hemidia
phragm. Conclusion. The volume of a pleural effusion can be estimated
from the chest radiograph appearance with a reasonable degree of accur
acy.