THE EFFECTS OF INNERVATION ON THE DEVELOPMENTAL EXPRESSION OF CA2-ACTIVATED K+ CURRENTS IN EMBRYONIC PARASYMPATHETIC NEURONS ARE NOT ACTIVITY-DEPENDENT()

Authors
SUBRAMONY P DRYER SE
Citation
P. Subramony et Se. Dryer, THE EFFECTS OF INNERVATION ON THE DEVELOPMENTAL EXPRESSION OF CA2-ACTIVATED K+ CURRENTS IN EMBRYONIC PARASYMPATHETIC NEURONS ARE NOT ACTIVITY-DEPENDENT(), Developmental brain research, 91(1), 1996, pp. 149-152
Citations number
18
Categorie Soggetti
Neurosciences
Journal title
Developmental brain research → ACNP
ISSN journal
01653806
Volume
91
Issue
1
Year of publication
1996
Pages
149 - 152
Database
ISI
SICI code
0165-3806(1996)91:1<149:TEOIOT>2.0.ZU;2-M
Abstract
Chronic blockade of synaptic transmission in ovo using mecamylamine, a neuronal nicotinic receptor antagonist, caused a large increase in na turally occurring cell death in the embryonic chick ciliary ganglion. However, the Ca2+-activated K+ currents in embryonic day 13 mecamylami ne-treated ciliary ganglion neurons were indistinguishable from those of saline-treated controls. Therefore, the trophic effect of pregangli onic innervation on the developmental expression of Ca2+-activated Kcurrent is not dependent upon intact nicotinic cholinergic synaptic tr ansmission and may instead be mediated by a nerve terminal-derived dif ferentiation factor.