FOREIGN-BODY REACTION TO EXOGENOUS PULMONARY SURFACTANT IN AN INFANT WITH HYDROPS AND CARDIOMYOPATHY

We present a hydropic infant who received exogenous surfactant and who had Noonan phenotype with hypertrophic cardiomyopathy. The infant had clinically diagnosed stridor for which bronchoscopy did not identify an origin. He died at 30 days of age. The bronchioles showed numerous eosinophilic plugs with a foreign body giant cell reaction. The plugs were positively immunostained with anti-aposurfactant protein B.