ADENOCARCINOMA OF MINOR SALIVARY-GLAND ORIGIN WITH SKELETAL METASTASIS IN A CHILD

Primary epithelial neoplasms of the salivary gland in children are unc ommon but are well recognized and occur principally in the major saliv ary glands. The purpose of this report is to document our experience w ith an adenocarcinoma of the buccal submucosa (one of several sites of minor salivary gland tissue) that metastasized to multiple bones as t he initial sites of distant disease after a local recurrence. The clin ical history, imaging studies, and microscopic sections including immu noperoxidase studies were evaluated from the many tumor, local recurre nce, and a metastatic lesion from the femur The histopathologic featur es and immunohistochemical phenotype of the adenocarcinoma in the bucc al submucosa supported its salivary gland origin. This case of adenoca rcinoma of the intraoral buccal tissues independent of the parotid gla nd in a 12-year-old-female is an unusual clinical presentation of a sa livary gland neoplasm in childhood, and its ability to metastasize to distant skeletal sites is also remarkable in terms of a primary saliva ry gland carcinoma regardless of age at diagnosis.