DOWN-REGULATION OF NA CHANNEL EXPRESSION BY A23187 IN N1E-115 NEUROBLASTOMA-CELLS

Authors
HIRSH JK QUANDT FN
Citation
Jk. Hirsh et Fn. Quandt, DOWN-REGULATION OF NA CHANNEL EXPRESSION BY A23187 IN N1E-115 NEUROBLASTOMA-CELLS, Brain research, 706(2), 1996, pp. 343-346
Citations number
19
Categorie Soggetti
Neurosciences
Journal title
Brain research → ACNP
ISSN journal
00068993
Volume
706
Issue
2
Year of publication
1996
Pages
343 - 346
Database
ISI
SICI code
0006-8993(1996)706:2<343:DONCEB>2.0.ZU;2-Z
Abstract
Growth of cultured N1E-115 neuroblastoma cells in 1 mu M A23187 for 2 days to elevate internal Ca reduced both membrane Na current and the t ransient, but not steady state, component of outward K current. Na cha nnel mRNA abundance was reduced by an average value of 45% without eff ect on Kv3.1. Increases in internal Ca may therefore control excitabil ity by independent regulation of Na and K channel mRNA abundance in ne urons.