STEREOSPECIFIC PREPARATION OF AN EXCITATORY AMINO-ACID ANTAGONIST WITH D-HYDANTOINASE FROM AGROBACTERIUM-TUMEFACIENS AS A BIOCATALYST

Authors
DURHAM DR WEBER JE
Citation
Dr. Durham et Je. Weber, STEREOSPECIFIC PREPARATION OF AN EXCITATORY AMINO-ACID ANTAGONIST WITH D-HYDANTOINASE FROM AGROBACTERIUM-TUMEFACIENS AS A BIOCATALYST, Applied and environmental microbiology, 62(2), 1996, pp. 739-742
Citations number
13
Categorie Soggetti
Microbiology,"Biothechnology & Applied Migrobiology
Journal title
Applied and environmental microbiology → ACNP
ISSN journal
00992240
Volume
62
Issue
2
Year of publication
1996
Pages
739 - 742
Database
ISI
SICI code
0099-2240(1996)62:2<739:SPOAEA>2.0.ZU;2-2
Abstract
Extracts of Agrobacterium tumefaciens were used to mediate the stereos pecific conversion of a racemic hydantoin to a carbamyl D-amino acid d erivative, which is a precursor to -2-amino-4,5-(1,2-cyclohexyl)-7-pho sphonoheptanoic acid (ACPA). ACPA has therapeutic value as an excitato ry amino acid antagonist.