FREQUENCY OF ABNORMAL KARYOTYPES AMONG ABORTUSES FROM WOMEN WITH AND WITHOUT A HISTORY OF RECURRENT SPONTANEOUS-ABORTION

Objective: To compare the frequency of chromosomal abnormalities in pr oducts of conception from women with and without a history of recurren t spontaneous abortion. Design: Retrospective analysis of prospectivel y collected material. Setting: Private practice at the Genetics and IV F Institute, Fairfax, Virginia and Grupo de Reproduccion AGY y Asociad os, Mexico City, Mexico. Patients: Women with (n = 94) and without (n = 130) a history of recurrent spontaneous abortion who had a spontaneo us abortion between January 1, 1992 and November 1, 1994. Intervention : Chromosomal analysis performed on products of conception using stand ard G-banding technique. Main Outcome Measure: The percentage of chrom osomal abnormalities among products of conception from women with and without recurrent spontaneous abortion was compared. Results: Among pr oducts of conception from women with recurrent spontaneous abortion, 5 7% (54/94) had abnormal and 43% (40/94) had normal chromosome analyses . Products of conception from women without recurrent spontaneous abor tion had abnormal chromosome analyses in 57% (74/130) and normal resul ts in 43% (56/130). Conclusions: No differences in frequency of abnorm al karyotype were observed in products of conception from women with r ecurrent spontaneous abortion compared with women without recurrent sp ontaneous abortion.