THE ROLE OF NUCLEAR IMPORT AND EXPORT IN INFLUENZA-VIRUS INFECTION

Infection with influenza virus involves a complex series of nuclear im port and export events. Early in infection, incoming viral ribonucleop roteins (vRNPs) are imported into the nucleus. Later, viral transcript s are exported from the nucleus, newly synthesized structural proteins are transported back into the nucleus and, finally, newly assembled v RNPs are exported. All these import and export steps, and, in particul ar the bidirectional traffic of vRNPs rely on the transport machinery of the cell, but are regulated both by viral and cellular factors. The viral M1 protein serves as the master organizer in determining the di rectionality of vRNP transport.