ALLOGENEIC BONE-MARROW TRANSPLANTATION IN A PATIENT WITH HYPEREOSINOPHILIC SYNDROME

We describe a 32-year-old man with idiopathic hypereosinophilic syndro me (HES) who presented with pulmonary dysfunction, thrombocytopenia, l ymphadenopathy, and hepatosplenomegaly. The patient developed progress ive disease on prednisone and hydroxyurea therapy, and he underwent a successful allogeneic bone marrow transplantation (BMT). The patient i s asymptomatic with no evidence of eosinophilia 30 months after transp lantation, There is currently no cure for patients with HES, and BMT s hould be considered in selected patients. (C) 1996 Wiley-Liss, Inc.