SAFETY AND EFFICACY OF PURIFIED FACTOR-IX CONCENTRATE AND ANTIFIBRINOLYTIC AGENTS FOR DENTAL EXTRACTIONS IN HEMOPHILIA-B

This study evaluated the safety and efficacy of combined treatment wit h E-aminocaproic acid or tranexamic acid and monoclonal antibody purif ied factor IX (MAb factor IX) for prophylaxis against bleeding in eigh t hemophilia a patients undergoing nine dental extraction procedures, All patients achieved excellent hemostasis without clinical evidence o f thrombosis, there were no significant changes in hemoglobin or hemat ocrit or in markers of hemostatic system activation (prothrombin fragm ent F-1+2, fibrinopeptide A, and fragment B beta(15-42)) after surgery . Thus, a highly purified factor IX concentrate and antifibrinolytic t herapy can be effectively and safely combined in hemophilia a patients undergoing dental extractions. (C) 1996 Wiley-Liss, Inc.